Clinical trial of proton craniospinal irradiation for leptomeningeal metastases
نویسندگان
چکیده
منابع مشابه
Standardized treatment planning methodology for passively scattered proton craniospinal irradiation
BACKGROUND As the number of proton therapy centers increases, so does the need for studies which compare proton treatments between institutions and with photon therapy. However, results of such studies are highly dependent on target volume definition and treatment planning techniques. Thus, standardized methods of treatment planning are needed, particularly for proton treatment planning, in whi...
متن کاملClinical Implementation of Robust Optimization for Craniospinal Irradiation
With robust optimization for spot scanning proton therapy now commercially available, the ability exists to account for setup, range, and interfield uncertainties during optimization. Robust optimization is particularly beneficial for craniospinal irradiation (CSI) where the large target volume lends itself to larger setup uncertainties and the need for robust match lines can all be handled wit...
متن کاملCyberknife Radiosurgery and Concurrent Intrathecal Chemotherapy for Leptomeningeal Metastases: Case Report of Prolonged Survival of a HER-2+ Breast Cancer Patient Status-Post Craniospinal Irradiation
Leptomeningeal disease (LMD) from breast cancer is usually a rapidly fatal condition, with median overall survival reported to be 15 weeks. Conventional treatment for LMD includes craniospinal irradiation and intrathecal (IT) methotrexate. However, the role of stereotactic radiation for leptomeningeal disease remains poorly defined. This case report describes our experience using Cyberknife rad...
متن کاملLeptomeningeal Metastases
1. Carcinomatous meningitis (metastases caused by carcinoma such as lung and breast) 2. Meningeal gliomatosis (dissemination of CSF caused by malignant glial tumors) 3. Leptomeningeal metastases secondary to other underlying solid tumors (e.g., rhabdomyosarcoma, neuroblastoma, medulloblastoma, other primitive neuroectodermal tumors) 4. Lymphomatous meningitis (metastases caused by lymphoma) 5. ...
متن کاملCase Report of Bone Marrow-Sparing Proton Therapy Craniospinal Irradiation for Central Nervous System Myelomatosis
Central nervous system (CNS) involvement is rare but it is an increasingly recognized complication of the multiple myeloma. The craniospinal radiotherapy is a standard treatment option, however, it may be challenging to deliver due to hematologic toxicity in the patients with multiple prior systemic therapies. We report a case of CNS myelomatosis in a patient with prior stem cell transplant mul...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neuro-Oncology
سال: 2020
ISSN: 1522-8517,1523-5866
DOI: 10.1093/neuonc/noaa152